Description
For Irritated Skin: Soothing & Nourishing High-Density Cream
Point 1: Deep Soothing, Moisturizing, & Nutrition
This high-density cream is crafted to soothe, hydrate, and nourish dry, irritated skin. Packed with premium ingredients, it’s designed to restore and maintain your skin’s health.
Key Ingredients & Benefits
- PDRN (1000ppm): A premium extract derived from salmon testis, delivering essential nutrition to rejuvenate and strengthen the skin.
- 11 Kinds of Peptides: Support skin elasticity and repair for a youthful, plump appearance.
- Plant-Based Squalane: Enhances hydration, mimicking your skin’s natural oils for a softer, smoother texture.
- Ceramide NP: Restores the skin barrier, locking in moisture to prevent dryness.
- Macadamia Seed Oil: Rich in fatty acids, it deeply nourishes and revitalizes parched skin.
- Panthenol: Known for its calming and healing properties, ideal for sensitive skin.
- Oil Complex & Soothing Complex: Provide comprehensive care, balancing hydration and comfort.
This cream’s high-density formulation ensures powerful hydration and nutrient delivery, preventing moisture loss while improving dry and rough skin texture.
Point 2: Elasticity & Wrinkle Care
As a functional cosmetic for wrinkle improvement, this cream boosts skin elasticity, helping to smooth fine lines and restore firmness.
Point 3: Safe for Sensitive Skin
Formulated with sensitive skin in mind, this cream is:
- Dermatologist-Tested (German Dermatest Certified): Proven safe for all skin types.
- EWG Green Grade Ingredients: Contains only safe, non-irritating components.
- Unscented & Gentle: Perfect for those with easily irritated or reactive skin.
Who Should Use This Cream?
- Individuals with dry, flaky skin, especially during seasonal transitions.
- Those with tired or sensitive skin caused by environmental stressors.
- Anyone seeking a mild, low-irritation formula for soothing and restoring skin health.
Experience the ultimate care for irritated skin with this premium, multifunctional cream. Say goodbye to dryness, wrinkles, and sensitivity for a healthier, more radiant complexion.

































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Cassandra Elyse Marks from Los Angeles, USA –
Embracing this cream has transformed my approach to skincare! Living in the bustling urban pulse of Los Angeles, pollution often taints our complexions. I discovered I.st Dermo PDRN Rejuvenation Cream when searching for hydration amidst California’s sun-soaked rays and sporadic chill from coastal breezes. Its luscious texture caressed my weary skin instantly—a nourishing blanket brimming with Peptides invigorating each layer back to life.
This fusion doesn’t just moisturize; it mirrors vitality reminiscent of tree-rich LA parks after a rejuvenating rainstorm! Skin seems ‘reconstructed’ like buildings returning youthful elegance through restorative artistry—a feat rare among typical creams these days!
Jade Williamson from Vancouver, Canada (verified owner) –
OMG, this I.st Dermo cream has totally transformed my irritated skin! My face was like a dry desert before; now it’s soft and silky. It’s such an awesome blend of rich ingredients that you can practically feel working its magic. The PDRN really had me curious – who would’ve thought salmon testis could do wonders?! 🤔 And the smell is so pleasant – not too overpowering but still luxe. Can’t recommend it enough if you’re feeling patchy or rough around the edges!
Célestine Lavoie from Annecy, France (verified owner) –
En toute honnêteté, j’étais assez sceptique à l’idée d’utiliser cette crème I.st Dermo. Il est vrai que beaucoup de produits promettent monts et merveilles pour la peau sans jamais livrer les résultats escomptés. Pourtant, dès la première application de ce soin hautement concentré en PDRN, mes réserves ont rapidement disparu. Sa texture veloutée glisse comme un rêve sur le visage; c’est comme offrir un véritable banquet à ma peau! Au bout de quelques jours seulement, elle se sent plus souple et hydratée qu’avant — je ne pouvais pas demander mieux dans une région aussi changeante que celle des Alpes françaises où le climat joue souvent des tours vicieux au derme.
Skye L. from Colorado Springs, USA –
OMG, have you tried this cream?! It’s a total game changer! I’ve been battling these dry patches ever since winter kicked in here in the chilly Rockies. 🏔️ Like, who knew salmon extracts could do wonders for your face? This stuff is not just hydrating; it’s downright nurturing! I lather it on and my skin feels like it’s ready to party again! Super rich yet absorbs fast – no greasy aftermath. And let me tell ya, after two weeks of using it nightly, I’m glowing up even under those gray skies! If you’re serious about sorting out that moisture issue – trust me on this one!
Nina MacMillan from Auckland, New Zealand –
After a few weeks of using this cream, my skin is singing praises! Its softness feels like velvet—no irritation, just pure calmness. Truly a game changer for those needing gentle nourishment!
Giulia Ricci from Roma, Italia (verified owner) –
Ragazzi, devo dirvi che questa crema I.st Dermo è la scoperta del secolo! Ho la pelle super irritata per colpa dei cambiamenti di clima e ho provato mille prodotti. Questa qui ha il potere di coccolarmi! Dopo appena qualche giorno, la mia pelle sembrava rinascita: più idratata e nutrita. Gli ingredienti come il PDRN dal testicolo di salmone suonano strani ma sono miracolosi! Inoltre, amo che contiene squalano vegetale; mi fa sentire come se stessi applicando un abbraccio sulla faccia. Sicuramente non posso farne a meno ora!
Zubair from Karachi, Pakistan –
So, I just got the I.st Dermo PDRN Rejuvenation Cream after hearing all the buzz around it. Initially, I was a bit hesitant ’cause I’ve tried heaps of creams that promised miracles but underdelivered. However, upon trying this one, wowza! The texture is rich yet melts right into my skin without feeling heavy at all. You can tell it’s packed with good stuff like those peptides and squalane – they really work wonders for hydration! My face felt plumper almost instantly and super soft throughout the day. And lemme tell ya about my irritation; it calmed down like a champ! Safe to say I’m officially on board with this product now.
Megan from Bristol, UK –
I just started using the I.st Dermo PDRN Rejuvenation cream, and honestly, I’m pretty chuffed with it! My skin was feeling all sorts of dry and irritated from this cold snap we’re having. This stuff is so rich—it glides on like butter but absorbs quickly too. The squalane really makes a difference; my skin feels soft without that greasy vibe some creams leave behind. After a week of use, I’ve noticed that pesky dryness fading away—like magic! Plus, knowing it’s got those fancy peptides to help out with elasticity has me stoked about keeping my youthful glow. Definitely recommend it if you want something nourishing for your face.
Jessica from Melbourne, Australia –
Alright, so I’ve been tryin’ out the I.st Dermo PDRN Rejuvenation Cream for a few weeks now and let me tell ya, it’s pretty darn impressive. My skin can be real finicky sometimes—dry patches here and there—and this cream’s got my back! The consistency is thick but it melts into your skin like butter. And that salmon testis extract? Sounds odd at first, but man does it make my face feel nourished! Plus, the blend of peptides has seriously given my cheeks that plump look again without feeling greasy or heavy. It even calmed down some irritation after using retinol recently. Honestly wasn’t expecting such great results from something new on the market; this one’s sticking around in my routine for sure!
Lucy from Edmonton, Canada –
I recently got my hands on the I.st Dermo PDRN Rejuvenation Cream, and let me tell you, it’s a game changer! My skin tends to freak out from time to time, especially with all this dry winter air we’ve been having. This cream feels super rich but absorbs quickly – no greasy aftermath here! The squalane and ceramide NP are legit lifesavers for keeping that moisture locked in. And wow, did you see there’s salmon extract? Sounds wild, but it’s packed with nutrients that really gave my complexion a boost. My skin’s feeling smoother than ever and definitely more plump; honestly couldn’t be happier with how revitalized it looks now. If your skin needs some TLC like mine did, give this one a whirl!
Jalisa from Chicago, USA –
I keep coming back to the I.st Dermo PDRN Rejuvenation Cream, and let me tell you why. My skin’s been through quite a bit – from harsh winters in Chicago to those steamy summer days, it’s all over the place! This cream has truly become my go-to remedy for irritation and dryness. The moment I slather it on, it’s like an instant hug for my face. The PDRN is magical; I’ve noticed how much more vibrant and elastic my skin feels after consistent use. Plus, that plant-based squalane really gives me that hydrated glow without feeling greasy. I’ve tried other products before but honestly? None have worked as well as this one has for keeping my sensitive skin calm and nourished during every season.
Jess from London, UK –
I’ve gotta say, I was pretty skeptical at first with this I.st Dermo PDRN Rejuvenation cream. The whole salmon extract thing? Just didn’t sound right. But y’all, after using it for a few weeks, my skin feels so much softer and less irritated! It really nailed that deep hydration promise—especially during these chilly mornings in London where the air is just brutal on your face. And those peptides? They’re like little fairy godmothers boosting elasticity and keeping things plump! No more flaky patches; just smooth sailing now. For anyone who’s dealing with dry or cranky skin—def give this one a whirl.
Cleo from Cape Town, South Africa (verified owner) –
I was dealing with this awful dryness around my cheeks that made me feel like a desert! Tried the I.st Dermo PDRN Rejuvenation cream on a whim after reading about its hydrating powers. From the first application, it felt rich but absorbed so quickly—no greasy aftermath, just silky softness! The ceramide NP really locked in moisture and evened out my skin tone over time. Honestly, can’t believe how much better I feel showing off my face now; it’s like giving your skin a warm hug without any heaviness. Plus, those peptides are magic for elasticity—I’ve noticed such improvement since using it!